Claudine Margaret Castelo Barretto, was born on July 20, 1979 in Manila, Philippines. She is the daughter of Miguel Alvier Barretto and Estrella Santiago Castelo. Siblings include Miguel Jr., Michelle, Joaquin, Geraldine, Gretchen and Marjorie.She married actor Raymart Santiago on March 27, 2006 at the Tagaytay Highlands. They have an adopted daughter, Sabina Natasha and their first son, Rodrigo Santino, which Claudine gave birth on July 19, 2007, a day before the couple's birthday.
Claudine attended high school at South Merville in Paranaque. She wanted to take Speech and Theater at the University of the Philippines to better herself in acting.
The young actress started appearing in stage plays while undergoing a workshop with Repertory Philippines in 1992.
On May 14, 2005, Claudine won her first best actress award from the 1st Luna Awards for the movie Milan. And on June 24, 2005, she won again for the movie Milan from the 53rd FAMAS Awards.
She won three awards for the movie Nasaan Ka Man from the 8th Pasado Awards on March 15, 2006, 22nd PMPC Star Awards for Movies on June 30, 2006, and 54th FAMAS Awards.
She also won the best actress award for the movie, Dubai, from Maria Clara Awards.
Other awards Claudine won were PMPC Star Awards for TV, Best TV Personality Award 1997, for the episode Kasunduan of Star Drama Presents.
Parangal Ng Bayan, Best Young Actress 1999, for Mula sa Puso, Starlight Cultural Foundation, Most Popular Movie/Teen Star of the Year 2000, PMPC Star Awards for TV, Best Female Variety Show Host, 2003, for ASAP Mania, German Moreno Youth Achievement Award, 2003, and MTV Style Awards, Favorite Stylish Leading Lady 2004. She also won Guillermo Mendoza Scholarship Foundation, Box Office Queen 2003, for Kailangan Kita, Queen of RP Movies 2004, for Milan, and Box Office Queen 2006, for Sukob.